Africa is mankind’s ancestral home and the store of its greatest wealth of genetic diversity as well as an equally rich social and cultural heritage. Recent advances in genomics offer new and powerful tools and techniques which allow us to dissect and analyze the genetic structure of individuals, families and populations at unprecedented levels of detail and with nearly global coverage of the variation they contain and affords us new avenues to interpret this variation in the context of biology, history and environment, furthering our understanding of all of these and their relation to the health and wellbeing of individuals and populations worldwide. The application of these tools and technologies to African populations offers unique challenges and opportunities which must be met if their full potential for improving the lives and livelihoods of Africans across the continent is to be realized. Sudan is a microcosm of the diversity of the African continent, neighboring regions and beyond and is fully representative of these challenges and opportunities. As a step towards addressing them, we propose a series of events under the theme of “Genomics and Human Health in Africa” , bringing together relevant stakeholders including scientific and research communities , health care providers and policy makers from across the continent together with international partners and collaborators.