Exomes Analysis reveals miRNA-646 And miRNA-4739 as novel Schizophrenia biomarkers
Mohamed Abdalhameed Alnor- MBBS. Msc. MD. University of Khartoum, Sudan
AZA Elshafi Khadir-MBBS. Msc. University of Khartoum, Sudan
Muntaser El Tayeb Ibrahim, B.Sc. M.Sc. Ph.D. University of Khartoum, Sudan
Background: Schizophrenia is one of the most common psychiatric disorders, which is associated with a high level of disability. Although there is growing evidence that genes are implicated in its etiology, the environmental and epigenetic factors remain one of the major players in modulating the disease. This complex pattern of inheritance rendered exploring other processes that may govern genes actions and interactions as of prime importance. Recently the microRNA has emerged as a promising factor in understanding the mechanism behind many disorders, Schizophrenia is one example.
Aim: We aimed to study miRNAs variants that are implicated in the etiology of Schizophrenia in five exomes from 2 Sudanese families. Three siblings are from family one -2 of them were diagnosed with schizophrenia- and 2 siblings are from the second family (one of them is affected).
Results and conclusion: One of the interesting findings is the SNP rs1700 in the 3\ UTR of FSTL1 gene, which was stated as Schizophrenia susceptibility variant, and target for many miRNAs was found to be heterozygote in the 2 controls and absent in the 3 cases. The microRNAs; miRNA-646, and miRNA-4739 plus many others microRNAs are proposed to be a novel Schizophrenia biomarker.