Rugumisa poster

Rugumisa poster

VAGINAL MICROBIOTA AND RISK OF PRETERM BIRTH IN TANZANIAN WOMEN ATTENDING PRENATAL CARE AT MUHIMBILI NATIONAL HOSPITAL.

Rugumisa, B. T. 1 2

1 University of Dar es Salaam, Department of Molecular Biology and Biotechnology

2 Sponsored by the Swedish International Development Agency (SIDA)

Preterm birth is defined as birth to a live baby before gestational age of 37 weeks. It is a leading cause of under-five children mortality and it contributes to 50% of all neonatal deaths globally. In Tanzania the prevalence of preterm birth is 15.3%. Among identified risk factors for preterm birth are maternal vaginal microbiota and black race. The objective of this study is to evaluate the vaginal microbiota composition throughout pregnancy and look for microbial composition characteristics that can be regarded as signatures of risk of preterm birth in a group of women from Tanzania.

The study will involve 24 women (12=preterm delivery and 12=term delivery). Vaginal swabs will be collected once in every trimester of pregnancy and analyzed using metabarcoding of the V4-V6 region of bacterial 16S rRNA gene by Illumina MiSeq platform. Bacterial sequence reads will be analyzed under QIIME pipeline. The microbiota within and between groups will be analyzed using Shannon and Jaccard’s diversity indexes respectively.

This study has no results yet as it is still in the subject recruitment and sample collection processes.

Key words: preterm birth, vaginal microbiota, Tanzania

 

Presenter: Rugumisa, B. T. 1 2

1 University of Dar es Salaam, Department of Molecular Biology and Biotechnology

2 Sponsored by the Swedish International Development Agency (SIDA)

 

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