DELETION OF GLUTATHIONE S-TRANSFERASE THETA 1

DELETION OF GLUTATHIONE S-TRANSFERASE THETA 1

DELETION OF GLUTATHIONE S-TRANSFERASE THETA 1 IN FOUR SUDANESE ETHNIC GROUPS

Anadil Ahmed Alsubki Alhassan1, Muntaser  Eltayeb Ibrahim2

1 Department of Molecular Biology, Institute of endemic disease, Qasr street, Khartoum, Sudan,  anadilalsubki@gmail.com

2Department of Molecular Biology, Institute of endemic disease, Qasr street, Khartoum, Sudan,mibrahim@iend.org

 Background: Glutathione S-transferases (GSTs) are drug-metabolizing enzymes important in the transformation of xenobiotics, carcinogens, oxygen free radicals and drugs. Pharmacogenomics researches suggested interethnic variation in GST allele’s frequencies. Polymorphisms of GST genes contribute to susceptibility to cancer, environmental risk factors and variability in pharmacotherapy responses.

Aim: To determine the prevalence of GSTT1 null genotype in different ethnic groups and if ethnicity has a role in the allelic distribution.

Individuals and method: GSTT1 null allele genotyped by Multiplex PCR in 120 healthy individuals .

Result:  Hausa and Nilotic have the highest frequencies of the null allele, Beja Bani Amir has the lowest frequency, Beja Bani Amir and Beja Hadendowa frequencies are different from each other although they belong to the same ethnic group ,however, the difference is not statistically significant by Fisher exact test.

Conclusion: Ethnic differences has no effect in GSTT1 null genotype disturbution in groups under study.

 

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