AN ASSOCIATION OF FGFR2 RS2981582 WITH BREAST CANCER AMONG SUDANESE PATEINTS: A POTENTIAL BIOMARKER FOR BREAST CANCER PREDICTION
Sajda Mustafa Satti Abd Elgader1,2, Mai Abdul Rahman Masri2
1 Department of Biology and Biotechnology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan firstname.lastname@example.org.
2Genetics and Molecular biology lab, Center of cell and molecular biology research, Department of Zoology, Faculty of Science, University of Khartoum, Khartoum, Sudan. Mai_masri@hotmail.com.
Aim: The current study targeted the role of the C/T SNP (rs2981582) of the FGFR2 gene and some non-genetic risk factors on the risk of breast cancer among Sudanese females. The interaction between that SNP and other known risk factors was also evaluated.
Background: The rs2981582 single nucleotide polymorphism in the Fibroblast Growth Factor Receptor 2 gene has been constantly associated with an increased risk of susceptibility to breast cancer across several human populations.
Methods: DNA was extracted and PCR-RFLP data from 81 cases and 81 controls was analyzed.
Results: The risk allele (T allele) of the rs2981582 polymorphism was associated with an increased risk of breast cancer (P-value= 0.0017) (OR =2.2, CI95%=1.34 to 3.53). Breast cancer risk, significantly, increased with TT genotype (P-value =0.0023) (OR=1.711 CI95%=1.16 to 4.04) when compared to the other two genotypes (CC and CT). Significant association was also encountered between history of benign tumors (P-value = 0.0001), and breast cancer in first degree relatives (P-value=0.045) (OR=7.22 CI95%=1.047 to 81.2) in cases carrying this polymorphism.
Conclusions: Our findings suggest that FGFR2 rs2981582 is significantly associated with breast cancer susceptibility in Sudanese women and present a potential biomarker for breast cancer prediction.