Genetic Variant of Vitamin D Receptoradmin
Genetic Variant of Vitamin D Receptor Gene Polymorphism in Osteoporotic Postmenopausal Sudanese Women Screened by Dual Energy X-ray Absorptiometry (DEXA)
Zeinab Hatim Abass1*, Amar M. Ismail2, Kamil A. Braima3, Mahmood A.Abdulla Hassan4, Siham M. A. Bakhit5
1 Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Karary University, Khartoum, Sudan. 2 Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.3 Department of Parasitology, Faculty of Veterinary, Murdoch University, Perth, Australia. 4Department of Biomedical Science, University of Malaya, Kuala Lumpur, Malaysia. 5Vice Chancellor, Alzaiem Alazhari University, Khartoum, Sudan.
Aim: A study to evaluate the vitamin D receptor (VDR) gene polymorphisms and its association with bone density among osteoporotic postmenopausal women in Sudan is reported. Method: A cross-sectional study involving 121 postmenopausal women was conducted, and based on the DEXA results, the subjects were classified into three groups, osteoporotic,T-score(≥ -2.5), osteopenia,T-score(-1 to -2.5) and normal, T-score(≤ -1) as the control group. Cdx2 single nucleotide polymorphisms (SNPs) in VDR were measured using RT-PCR TaqMan. Result The VDR SNP Cdx2 (rs11568820) AA genotype was found to be associated with osteoporosis and bone mineral density (BMD) at both the total hip and lumbar spine (L1–L4) (P=0.038, AOR 2.26 and P=0.017, AOR 8.1) under the additive and recessive model, respectively. No associations were observed among the other genotype polymorphisms (BsmI, TaqI, ApaI and FokI), bone mineral density (BMD), osteopenia and osteoporosis risk. This study is the first report of these findings from Sudan, which focused on VDR polymorphisms and bone health in the Sudanese population. Conclusion: The data suggest that genetic polymorphism in VDR Cdx2 SNP (rs11568820) is related to a higher risk of osteoporosis in postmenopausal Sudanese women.